ApexBio/(+)-Bicuculline/250mg/N1592,ApexBio,,ApexBio,apexbt,+,,Array.Array蚂蚁淘厂家直采.

产品名称：ApexBio/(+)-Bicuculline/250mg/N1592

产品编号：N1592

市场价：¥4000.00

场地：美国(厂家直采)

产品分类：蛋白类>聚合物>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$200.00

品牌： ApexBio

公司：ApexBio

公司分类：

商品介绍

Size	Price	Stock
10mM (in 1mL DMSO)	$100.00	In stock
100mg	$100.00	In stock
250mg	$200.00	In stock

Publications citing ApexBio Products

Nature.2017 Jan 19;541(7637):417-420.

Nature.2018 Nov;563(7731):407-411.

Nature.2018 Jun 13.

Nature.2018 Jun 27.

Nature.2018 Mar 29;555(7698):673-677.

Nature.2017 Sep 7;549(7670):96-100.

Nature.2016 Apr 21;532(7599):398-401.

Science.2016 Aug 5;353(6299)594-8

Nat Nanotechnol.2017 Dec;12(12):1190-1198.

Nature Biotechnology.2017 Jun;35(6):569-576

Nat Med.2018 Sep 17.

Cell.2018 Dec 21. pii: S0092-8674(18)31561-7.

Cell.Available online 25 October 2018.

Cell.2018 Sep 27. pii: S0092-8674(18)31183-8.

Cell.2018 Jun 28;174(1):172-186.e21.

Cell.2018 Feb 22;172(5):1007-1021.e17.

Cell.2017 Nov 30;171(6):1284-1300.e21.

Cell.2017 Aug 17. pii: S0092-8674(17)30869-3.

Cell.2017 Jul 13;170(2):312-323

Nat Med.2018 Jan 29.

Nat Med.2017 Nov;23(11):1342-1351.

Cell.2017 Apr 6;169(2):286-300.

Cell.2015 Aug 27;162(5):987-1002.

Cell.2015 Feb 12;160(4):729-44.

Nature Medicine.2017 Apr;23(4):493-500.

Cancer Cell.2018 May 14;33(5):905-921.e5.

Cancer Cell.2018 Apr 9;33(4):752-769.e8.

Cancer Cell.2018 Mar 12;33(3):401-416.e8.

Cancer Cell.2017 Aug 14;32(2):253-267.e5.

Nat Methods.2018 Jul;15(7):523-526.

Cell Stem Cell.2018 May 3;22(5):769-778.e4.

Cell Stem Cell.2017 Nov 20. pii: S1934-5909(17)30375-2.

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Quality Control

Quality Control & MSDS

View current batch:

Purity = 98.83%

COA (Certificate Of Analysis)
HPLC
NMR (Nuclear Magnetic Resonance)
MSDS (Material Safety Data Sheet)
Datasheet

Chemical structure

Biological Activity

Description	(+)-Bicuculline is a classical antagonist of GABAa.
Targets	GABAa
IC50

Protocol

Cell experiment [1]:
Cell lines	Primary cortical neurons from rat E18 embryos
Preparation method	The solubility of this compound in DMSO >10 mM. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.
Reacting condition	10 μM for 15–60 min
Applications	Bicuculline treatment could potentiate synaptic NMDAR signaling in the primary cortical neurons. Bicuculline led to a rapid decrease in STEP61 expression and a concomitant increase in the tyrosine phosphorylation of STEP substrates including GluN2B, Pyk2, and ERK1/2.
Animal experiment [2]:
Animal models	13-month old Fischer- 344 virgin female ovariectomized rats.
Dosage form	3.5 mg/kg( dissolved in sesame oil + 10% DMSO) daily by injection for 26 days
Application	The GABAA antagonist bicuculline attenuated progesterone-induced memory impairments in middle-aged ovariectomized rats.
Other notes	Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.
References: [1] Xu J1, Kurup P1, et al, Synaptic NMDA Receptor Activation Induces Ubiquitination and Degradation of STEP61. Mol Neurobiol. 2017 May 2. doi: 10.1007/s12035-017-0555-x. [2] Braden BB1, Kingston ML, et al, The GABAA antagonist bicuculline attenuates progesterone-induced memory impairments in middle-aged ovariectomized rats. Front Aging Neurosci. 2015 Aug 14;7:149. doi: 10.3389/fnagi.2015.00149. eCollection 2015.

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Chemical Properties

Cas No.	485-49-4	SDF	Download SDF
Synonyms	Bucuculline
Chemical Name	(6R)-6-[(5S)-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6H-furo[3,4-g][1,3]benzodioxol-8-one
Canonical SMILES	CN1CCC2=CC3=C(C=C2C1C4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3
Formula	C₂₀H₁₇NO₆	M.Wt	367.11
Solubility	≥13.1mg/mL in DMSO	Storage	Store at -20°C
Physical Appearance	A solid	Shipping Condition	Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.