ApexBio/DiscoveryProbe™ GPCR/G protein-related Compounds Panel/5mg/well/L1009,ApexBio,,ApexBio,apexbt,+,,Array.Array蚂蚁淘厂家直采.

产品名称：ApexBio/DiscoveryProbe™ GPCR/G protein-related Compounds Panel/5mg/well/L1009

产品编号：L1009

市场价：¥103200.00

场地：美国(厂家直采)

产品分类：蛋白类>聚合物>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$5160.00

品牌： ApexBio

公司：ApexBio

公司分类：

商品介绍

Size	Price	Stock	Qty
5mg/well	$5,160.00	In stock

Publications citing ApexBio Products

Nature.2017 Jan 19;541(7637):417-420.

Nature.2018 Nov;563(7731):407-411.

Nature.2018 Jun 13.

Nature.2018 Jun 27.

Nature.2018 Mar 29;555(7698):673-677.

Nature.2017 Sep 7;549(7670):96-100.

Nature.2016 Apr 21;532(7599):398-401.

Science.2016 Aug 5;353(6299)594-8

Nat Nanotechnol.2017 Dec;12(12):1190-1198.

Nature Biotechnology.2017 Jun;35(6):569-576

Nat Med.2018 Sep 17.

Cell.2018 Dec 21. pii: S0092-8674(18)31561-7.

Cell.Available online 25 October 2018.

Cell.2018 Sep 27. pii: S0092-8674(18)31183-8.

Cell.2018 Jun 28;174(1):172-186.e21.

Cell.2018 Feb 22;172(5):1007-1021.e17.

Cell.2017 Nov 30;171(6):1284-1300.e21.

Cell.2017 Aug 17. pii: S0092-8674(17)30869-3.

Cell.2017 Jul 13;170(2):312-323

Nat Med.2018 Jan 29.

Nat Med.2017 Nov;23(11):1342-1351.

Cell.2017 Apr 6;169(2):286-300.

Cell.2015 Aug 27;162(5):987-1002.

Cell.2015 Feb 12;160(4):729-44.

Nature Medicine.2017 Apr;23(4):493-500.

Cancer Cell.2018 May 14;33(5):905-921.e5.

Cancer Cell.2018 Apr 9;33(4):752-769.e8.

Cancer Cell.2018 Mar 12;33(3):401-416.e8.

Cancer Cell.2017 Aug 14;32(2):253-267.e5.

Nat Methods.2018 Jul;15(7):523-526.

Cell Stem Cell.2018 May 3;22(5):769-778.e4.

Cell Stem Cell.2017 Nov 20. pii: S1934-5909(17)30375-2.

HTS Facility Partners

Featured Products of the Panel

Catalog No.	Product Name	Summary	Targets	CAS Number	Smiles
A8454	Istradefylline (KW-6002)	Selective A2A receptor antagonist	GPCR/G protein\|Adenosine Receptor	155270-99-8	CCN1C2=C(C(=O)N(C1=O)CC)N(C(=N2)C=CC3=CC(=C(C=C3)OC)OC)C
B1007	AVE 0991	Agonist of angiotensin-(1-7) receptor	GPCR/G protein\|Angiotensin Receptor	304462-19-9	CCNC(=O)NS(=O)(=O)C1=C(C=C(S1)CC(C)C)C2=CC=C(C=C2)CN3C(=C(N=C3C4=CC=CC=C4)OC)C=O
A1435	CP-945598 HCl	CB1 antagonist,selective and high affinity	GPCR/G protein\|Cannabinoid Receptor	686347-12-6	CCNC1(CCN(CC1)C2=NC=NC3=C2N=C(N3C4=CC=C(C=C4)Cl)C5=CC=CC=C5Cl)C(=O)N.Cl
A5827	AM1241	Cannabinoid CB2 receptor agonist,potent and selective	GPCR/G protein\|Cannabinoid Receptor	444912-48-5	CN1CCCCC1CN2C=C(C3=CC=CC=C32)C(=O)C4=C(C=CC(=C4)[N+](=O)[O-])I
A2025	Plerixafor (AMD3100)	CXCR4 antagonist; CXCR7 agonist	GPCR/G protein\|CXCR	110078-46-1	C1CNCCNCCCN(CCNC1)CC2=CC=C(C=C2)CN3CCCNCCNCCCNCC3
A3802	SCH 527123	CXCR1 and CXCR2 receptors antagonist	GPCR/G protein\|CXCR	473727-83-2	CCC(C1=CC=C(O1)C)NC2=C(C(=O)C2=O)NC3=CC=CC(=C3O)C(=O)N(C)C
B1633	CTEP (RO4956371)	MGlu5 inhibitor	GPCR/G protein\|mGluR	871362-31-1	CC1=C(N=C(N1C2=CC=C(C=C2)OC(F)(F)F)C)C#CC3=CC(=NC=C3)Cl
A3616	MK-4305	OX1/OX2 atagonist,potent and selective	GPCR/G protein\|OX Receptor	1030377-33-3	CC1CCN(CCN1C(=O)C2=C(C=CC(=C2)C)N3N=CC=N3)C4=NC5=C(O4)C=CC(=C5)Cl
B2166	Ticagrelor	P2Y12 receptor antagonist	GPCR/G protein\|P2Y Receptor	274693-27-5	CCCSC1=NC2=C(C(=N1)NC3CC3C4=CC(=C(C=C4)F)F)N=NN2C5CC(C(C5O)O)OCCO
Download the GPCR/G protein-related Compounds Panel - XLSXDownload the GPCR/G protein-related Compounds Panel - SDF

Quality Control

Related Biological Data

Related Biological Data

Signaling Pathway

Glucagon Receptor Compare Products

Product Name	Glucagon Receptor	GLP-1 receptor
glucagon receptor antagonists 3	*
L-168,049	****
des-His1-[Glu9]-Glucagon (1-29) amide	*
MK 0893	****
glucagon receptor antagonists 2	*
glucagon receptor antagonists 1	*
GLP-1 (9-36) amide		*
Exendin-3 (9-39) amide		****

Product Name	Glucagon Receptor	GLP-1 receptor
Exendin-4		*****
BETP		*

Adenosine Receptor Compare Products

Adrenergic Receptor Compare Products

Adrenergic Receptor Inhibitors
Adrenergic Receptor Activators
Hover mouse over "" to show IC50

Product Name	Adrenergic Receptor	α receptor	α1 receptor	α1A receptor	α1B receptor	α1D receptor	α2 receptor	α2A receptor	α2B receptor	α2C receptor	α2D receptor	β receptor	β1 receptor	β2 receptor	β3 receptor	Other Targets
Sotalol												*
Metoprolol Tartrate													*
Tolazoline HCl		*
Naftopidil DiHCl			**													5-HT1A
Cisatracurium Besylate	*
Naftopidil			***
Bisoprolol fumarate													*
Maprotiline HCl	*
Terazosin HCl		*
Betaxolol													*
Betaxolol HCl													*
Phentolamine Mesylate		***
Timolol Maleate													****	****
ICI 118,551 hydrochloride													*	****	*
Silodosin			*
Alfuzosin HCl			*
Prazosin HCl			*						*							MT3 receptor
Prazosin			*						*							MT3 receptor
Doxazosin Mesylate			*
Carvedilol			****										*****	*****
Acebutolol HCl												*
Nebivolol													*****
Doxazosin			*
Ivabradine HCl	*
Alfuzosin			*
CGP 12177 hydrochloride													*****	****
RX 821002 hydrochloride							*
SDZ 21009												*				5-HT1A/1B
BRL 44408 maleate								****	**
(S)-(+)-Niguldipine hydrochloride				*												L-type Ca2+ channels
(R)-(-)-Niguldipine hydrochloride				*												L-type Ca2+ channels
CGP 20712 dihydrochloride													*****
RS 79948 hydrochloride								*****	*****	*****
A 80426 mesylate							****									5-HT
SNAP 5089				*****	**	**		*	**	**						L-type Ca2+ channels
RS 100329 hydrochloride				*****
TC-G 1000			**					***	***	***	*****
SKF 86466 hydrochloride							***
Rec 15/2615 dihydrochloride				****	*****	****
Atipamezole hydrochloride				*	*			****	*****	*****
L-748,337													**	**	****
JP 1302 dihydrochloride								*	*	***	*
Bucindolol			***										****	****		5-HT2A/2B
Labetalol HCl			*									*
Imiloxan hydrochloride							*
Alprenolol hydrochloride												*				5-HT1A
WB 4101 hydrochloride				*
Rauwolscine hydrochloride								****	****	*****						5-HT1A
												*
Setiptiline maleate							*									serotonin receptor
Setiptiline							*									serotonin receptor
Oxprenolol hydrochloride												*
Pronethalol hydrochloride												*
RS 17053 hydrochloride				*****	***	***
ARC 239 dihydrochloride								**	****		**
ICI 89406	*
Idazoxan hydrochloride								****	***	***
Efaroxan hydrochloride								***	***	*
2-MPMDQ							*
(S)-(-)-Atenolol													*
HEAT hydrochloride			*
2-PMDQ			*
Spiroxatrine										*						5-HT1A
Phenoxybenzamine HCl		**
												***
Metoprolol Succinate													*

Notes:1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)2.For more details about the compound, click on the product name of your interest.3."" represents potency. The higher the number of "" is, the more potent the inhibitor or activator is.

Advantages

Available in stock with overnight delivery and free shipping over $500
Cost-effective and competitive price to save your findings
Potent, selective and cell-permeable in inhibiting or activating target molecules
Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.)
Detailed files describing potency, selectivity and applications etc.
Supported by published data from top peer-reviewed journals
Guaranteed high quality with NMR and HPLC validation

Storage and Shipping Information

Solubility	Soluble in DMSO	Storage	Desiccate at -20°C
Packaging	96 well plate	Form	Powder
General tips	For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.
Shipping Condition	Evaluation sample solution : ship with blue iceAll other available size:ship with RT , or blue ice upon request

Background

A wide range of well-characterized bioactive molecules that covers various targets related to GPCR, including adenosine receptor, adrenergic receptor and CXCR etc. Facilitate your research towards the insights of cancer, neurological disorders and heart diseases etc. Applicable in cellular assays, animal models and drug screenings etc.

References

1. Wettschureck N, Offermanns S. Mammalian G proteins and their cell typespecific functions. Physiol Rev. 2005 Oct;85(4):1159-204.Abstract G protein-mediated signaling is employed by virtually all cells in the mammalian organism and is centrally involved in diverse physiological functions such as perception of sensory information, modulation of synaptic transmission, hormone release and actions, regulation of cell contraction and migration, or cell growth and differentiation. In this review, some of the functions of heterotrimeric G proteins in defined cells and tissues are described.

品牌介绍

ApexBio是用于生物学研究的肽和实验室试剂的主要提供商。我们在细胞凋亡，表观遗传学，癌症生物学等研究领域拥有广泛的产品线。Apexbio还提供定制服务，包括肽合成，抗体生产和测定开发。

公司介绍

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产品分类

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Growth Factors Nature Products Tag Peptides Biotinylation reagents and kits Others DNA/RNA Kit Screening Panel Signaling Pathways

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ApexBio/GSK837149A/5mg/C5075

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ApexBio/BLZ945/10mM (in 1mL DMSO)/B4899

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ApexBio/2-Imino-4-methylpiperidine (acetate)/10mg/C5658

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ApexBio/ACET/10mg/B7161

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ApexBio/GW788388/10mM (in 1mL DMSO)/A8301

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问答列表

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暂无问答

Product Name	Adrenergic Receptor	α receptor	α1 receptor	α1A receptor	α1B receptor	α1D receptor	α2 receptor	α2A receptor	α2B receptor	α2C receptor	α2D receptor	β receptor	β1 receptor	β2 receptor	β3 receptor	Other Targets
Guanfacine								*
Dexmedetomidine HCl			*				****
Dexmedetomidine			*				****
Medetomidine HCl			*				****
Medetomidine			*				****
Xylazine HCl							*
Isoprenaline HCl												*
Tetrahydrozoline HCl		*
Synephrine HCl		*
Guanabenz Acetate							****
Epinephrine HCl	*
Salbutamol Sulfate														*
Naphazoline HCl	*
Clonidine HCl							*
L-Adrenaline	*
DL-Adrenaline	*
Scopine			*
Ritodrine HCl														*
Oxymetazoline HCl			*				*
(R,R)-Formoterol														*
Formoterol Hemifumarate														****
Vilanterol trifenatate														*
Vilanterol														*
Mirabegron (YM178)															***
Salmeterol xinafoate														*
Salmefamol														*
Guanfacine hydrochloride								***
Levalbuterol tartrate														*
Adrenalone HCl			*
L-(-)-α-Methyldopa hydrochloride		*
Methyldopa		*
Tizanidine HCl							*
Tizanidine							*
Detomidine							*
Detomidine HCl							*
CGP 12177 hydrochloride															***
CL 316243 disodium salt															****
SR 59230A hydrochloride													**	**	***
L-755,507													**		*****
Procaterol hydrochloride														*
(S)-(-)-Pindolol															*	5-HT1A/1B
Pindolol															*	5-HT1A/1B
A 61603 hydrobromide		*
Zinterol hydrochloride													*	****
AH 11110 hydrochloride					***
ST 91							*
ZD 2079															*
ICI 215,001 hydrochloride															*
SR 58611A hydrochloride															*
B-HT 933 dihydrochloride							*
HOKU-81														*
(R)-(+)-m-Nitrobiphenyline oxalate								***	**	***
Cirazoline hydrochloride			*
Agmatine sulfate							*
Dihydroergocristine mesylate	*															5-HT receptordopaminergic receptors
Indacaterol Maleate												***
Indacaterol														*
RWJ 52353			**					**	**		****
Xamoterol hemifumarate													***	**
BRL 37344, sodium salt													*	*	**
ZD 7114 hydrochloride															*
Cimaterol												*
3-MPPI				*****	****	*****										5-HT1A
Epinephrine Bitartrate		*										*
Phenylephrine HCl			*
Terbutaline Sulfate														***
Dobutamine hydrochloride			*										*	*
Bambuterol												*

Product Name	Adenosine Receptor	Adenosine A1 R	Adenosine A2 R	Adenosine A2A R	Adenosine A2B R	Adenosine A3 R	Adenosine diphosphate (ADP) receptor	Other Targets
CGS 21680				***
Ticlopidine HCl							*
CGS 21680 HCl			***
Istradefylline (KW-6002)				****
Tozadenant				*
Preladenant				****
(±)-5"-Chloro-5"-deoxy-ENBA
SLV 320		*****		**	*	**
8-(3-Chlorostyryl)caffeine		*		***				MAO-B
XAC		****	**
PSB 0788					****
PSB 603					*****
MRS 1754		***		**	****	**
CGH 2466 dihydrochloride		***			****	****		p38 MAPKphosphodiesterase type 4D
SCH 58261				****
PSB 36		*****		**	**	*
ANR 94				***
XCC		***		*	***
SCH 442416				*****
LUF 5834		****		****	***	**
BAY 60-6583					****
TC-G 1004		***		*****
PSB 0777 ammonium salt				***
KW 3902		*****		**
8-Aminoadenine	*
NECA	*
MRS 1334						****
Lu AA 47070		**		****	**	*
PSB 11 hydrochloride		*		*		****
PSB 10 hydrochloride		*		*	*	*****
1,3-Dipropyl-8-phenylxanthine		*
MRE 3008F20		**		*		*****
2-Chloroadenosine		**		***		*
SDZ WAG 994		***
MRS 3777 hemioxalate						****
2"-MeCCPA		****
N6-Cyclopentyladenosine		****		**	*	***
DPCPX		****		**	*	*
LUF6000						*
ZM 241385				*
2-Cl-IB-MECA						*****
PSB 1115		*			***
GR 79236		****
CV 1808			*
2-Chloro-N6-cyclopentyladenosine		*****		*	*	***
CGS 15943		****		****	***	***
MRS 1706		**		**	****	**
HEMADO		**		*	*	****
PD 81723		*
VUF 5574						****
MRS 1220		**		***		*****