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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
ApexBio/DiscoveryProbe™ Endocrinology and Hormones-related Compounds Panel/5mg/well/L1008
产品编号:L1008
市  场 价:¥39800.00
场      地:美国(厂家直采)
产品分类: 蛋白类>聚合物>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$1990.00
品      牌: ApexBio
公      司:ApexBio
公司分类:
ApexBio/DiscoveryProbe™ Endocrinology and Hormones-related Compounds Panel/5mg/well/L1008
商品介绍
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Molarity CalculatorDilution Calculator
DiscoveryProbe™ Endocrinology and Hormones-related Compounds Panel

Catalog No.L1008
SizePriceStockQty
5mg/well
$1,990.00
In stock

Tel: +1-832-696-8203

Email: sales@apexbt.com

Worldwide Distributors

Sample solution is provided at 25 µL, 10mM.

Click and Customize the Panelwith your own choices of compounds/size/quantities/chemical forms etc.

Publications citing ApexBio Products

Nature.2017 Jan 19;541(7637):417-420.
Nature.2018 Nov;563(7731):407-411.
Nature.2018 Jun 13.
Nature.2018 Jun 27.
Nature.2018 Mar 29;555(7698):673-677.
Nature.2017 Sep 7;549(7670):96-100.
Nature.2016 Apr 21;532(7599):398-401.
Science.2016 Aug 5;353(6299)594-8
Nat Nanotechnol.2017 Dec;12(12):1190-1198.
Nature Biotechnology.2017 Jun;35(6):569-576
Nat Med.2018 Sep 17.
Cell.2018 Dec 21. pii: S0092-8674(18)31561-7.
Cell.Available online 25 October 2018.
Cell.2018 Sep 27. pii: S0092-8674(18)31183-8.
Cell.2018 Jun 28;174(1):172-186.e21.
Cell.2018 Feb 22;172(5):1007-1021.e17.
Cell.2017 Nov 30;171(6):1284-1300.e21.
Cell.2017 Aug 17. pii: S0092-8674(17)30869-3.
Cell.2017 Jul 13;170(2):312-323
Nat Med.2018 Jan 29.
Nat Med.2017 Nov;23(11):1342-1351.
Cell.2017 Apr 6;169(2):286-300.
Cell.2015 Aug 27;162(5):987-1002.
Cell.2015 Feb 12;160(4):729-44.
Nature Medicine.2017 Apr;23(4):493-500.
Cancer Cell.2018 May 14;33(5):905-921.e5.
Cancer Cell.2018 Apr 9;33(4):752-769.e8.
Cancer Cell.2018 Mar 12;33(3):401-416.e8.
Cancer Cell.2017 Aug 14;32(2):253-267.e5.
Nat Methods.2018 Jul;15(7):523-526.
Cell Stem Cell.2018 May 3;22(5):769-778.e4.
Cell Stem Cell.2017 Nov 20. pii: S1934-5909(17)30375-2.

HTS Facility Partners

HTS Facility Partners

Featured Products of the Panel

Catalog No.Product NameSummaryTargetsCAS NumberSmiles
A2150AndarineSelective androgen receptor agonistEndocrinology and Hormones|Androgen Receptor401900-40-1C(=O)NC1=CC=C(C=C1)OCC(C)(C(=O)NC2=CC(=C(C=C2)[N+](=O)[O-])C(F)(F)F)O
B1534AZD1981CRTh2 antagonist,potent and selectiveEndocrinology and Hormones|CRTH2802904-66-1CC1=C(C2=C(N1CC(=O)O)C=CC=C2NC(=O)C)SC3=CC=C(C=C3)Cl
A1428FulvestrantEstrogen receptor antagonist,high affinityEndocrinology and Hormones|Estrogen/progestogen Receptor129453-61-8CC12CCC3C(C1CCC2O)C(CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F
B1518Erteberel (LY500307)Erβ agonist, potent and selectiveEndocrinology and Hormones|Estrogen/progestogen Receptor533884-09-2C1CC2C(C1)C3=C(C=CC(=C3)O)OC2C4=CC=C(C=C4)O
B3238XCT790ERRα agonistEndocrinology and Hormones|Estrogen/progestogen Receptor725247-18-7COC1=C(C=CC(=C1)C=C(C#N)C(=O)NC2=NN=C(S2)C(F)(F)F)OCC3=C(C=C(C=C3)C(F)(F)F)C(F)(F)F
A2986ADL5859 HClδ-opioid receptor agonist,selectiveEndocrinology and Hormones|Opioid Receptor850173-95-4CCN(CC)C(=O)C1=CC=C(C=C1)C2=CC3(CCNCC3)OC4=C2C(=CC=C4)O.Cl
A8456JTC-801KOR-3 (NOP) receptor antagonist, high affinity and selectiveEndocrinology and Hormones|Opioid Receptor244218-51-7CCC1=CC=C(C=C1)OCC2=CC=CC=C2C(=O)NC3=CC4=C(C=C3)N=C(C=C4N)C.ClA8019Perindopril ErbuminePotent angiotensin-converting enzyme (ACE) inhibitorEndocrinology and Hormones|RAAS107133-36-8CCCC(C(=O)OCC)NC(C)C(=O)N1C2CCCCC2CC1C(=O)O.CC(C)(C)N
Download the Endocrinology and Hormones-related Compounds Panel - XLSXDownload the Endocrinology and Hormones-related Compounds Panel - SDF

Quality Control

Related Biological Data

MDV3100
KLK3 (top) and NKX3-1(bottom) expression which were the AR target genes in various resistant clones were analyzed by QPCR.All lines were pretreated with vehicle (−) or doxycycline (+) for 3 days before treatment with DMSO (left) or 10 μmol/L MDV3100 (right) for 24 hours in 10% FCS. TBP was used to normalize expression. Data represent mean ± SEM; n = 3. *, P < 0.05;="" **,="" p="">< 0.01="" (student="" t="" test).="" the="" f876l="" mutation="" is="" sufficient="" to="" induce="" genetic="" and="" phenotypic="" resistance="" to="" mdv3100.="">

Review (Georgia Regents University)

MDV3100
Comparison of different anti-androgen/AR compounds on TGF-β1/Smad3/MMP9 signaling in PCa cells. CWR22Rv1 cells treated with 10 μM CASO, 10 μM MDV, 10 μM ASC, 5 μM CTS, or vehicle for 3 days were harvested. The expressions of TGF-β1, p-Smad3, Smad3, MMP9, and GAPDH were analyzed by Western blot analysis. All of the experiments have been repeated twice independently. *, p< 0.05;="" **,="" p="">< 0.01;="" ***,="" p="">< 0.001.="" error="" bars,="" s.d.="" casodex="" and="" mdv3100="" enhanced="" tgf-beta,="" mmp9="" expression="" in="" cwr22rv1="" cells.="" whereas="" asc-j9="" and="" cts="" treatment="" did="" not.="">

Review (University of Glasgow )

MDV3100
Chronic exposure to ENZA resulted in autophagy. To mimic resistant to ENZA, C4-2B cells were subjected to 20 μM ENZA over a period of 3 months and selected for a sub-population of resistance cells (C4-2B+R). Upper panel showed acridine orange staining of autophagosome acidic vesicles as a marker for autophagy. Lower panel showed LC3-I/II protein expression in parental cells (control) and under chronic ENZA exposure-treated vehicle control, chloroquine (CQ) or CMI. β -Actin was used as the loading control.

Signaling Pathway

Androgen Receptor Compare Products
Estrogen/progestogen Receptor Compare Products
Opioid Receptor Compare Products

Advantages

  • Available in stock with overnight delivery and free shipping over $500
  • Cost-effective and competitive price to save your findings
  • Potent, selective and cell-permeable in inhibiting or activating target molecules
  • Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.)
  • Detailed files describing potency, selectivity and applications etc.
  • Supported by published data from top peer-reviewed journals
  • Guaranteed high quality with NMR and HPLC validation

Storage and Shipping Information

SolubilitySoluble in DMSOStorageDesiccate at -20°C
Packaging96 well plateFormPowder
General tipsFor obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.
Shipping ConditionEvaluation sample solution : ship with blue iceAll other available size:ship with RT , or blue ice upon request

Background

A wide range of well-characterized bioactive molecules that covers various targets related to endocrinology and hormones, including androgen receptor, estrogen/progestogen receptor and RAAS etc. Facilitate your research towards the insights of diabetes, thyroid disorders and cancer etc. Applicable in cellular assays, animal models and drug screenings etc.

References

1. Kaarbø M, Klokk TI, Saatcioglu F. Androgen signaling and its interactions withother signaling pathways in prostate cancer. Bioessays. 2007 Dec;29(12):1227-38.Abstract The androgen receptor (AR) is required for prostate cancer growth in all stages. This review focuses on AR function and AR-target genes and summarizes the major signaling pathways implicated in prostate cancer progression, their crosstalk with each other and with AR signaling. This complex network of interactions is providing a deeper insight into prostate carcinogenesis and may form the basis for novel diagnostic and therapeutic strategies.
品牌介绍


ApexBio是用于生物学研究的肽和实验室试剂的主要提供商。我们在细胞凋亡,表观遗传学,癌症生物学等研究领域拥有广泛的产品线。Apexbio还提供定制服务,包括肽合成,抗体生产和测定开发。


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