ApexBio/DiscoveryProbe™ Endocrinology and Hormones-related Compounds Panel/5mg/well/L1008,ApexBio,,ApexBio,apexbt,+,,Array.Array蚂蚁淘厂家直采.

产品名称：ApexBio/DiscoveryProbe™ Endocrinology and Hormones-related Compounds Panel/5mg/well/L1008

产品编号：L1008

市场价：¥39800.00

场地：美国(厂家直采)

产品分类：蛋白类>聚合物>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$1990.00

品牌： ApexBio

公司：ApexBio

公司分类：

商品介绍

Size	Price	Stock	Qty
5mg/well	$1,990.00	In stock

Publications citing ApexBio Products

Nature.2017 Jan 19;541(7637):417-420.

Nature.2018 Nov;563(7731):407-411.

Nature.2018 Jun 13.

Nature.2018 Jun 27.

Nature.2018 Mar 29;555(7698):673-677.

Nature.2017 Sep 7;549(7670):96-100.

Nature.2016 Apr 21;532(7599):398-401.

Science.2016 Aug 5;353(6299)594-8

Nat Nanotechnol.2017 Dec;12(12):1190-1198.

Nature Biotechnology.2017 Jun;35(6):569-576

Nat Med.2018 Sep 17.

Cell.2018 Dec 21. pii: S0092-8674(18)31561-7.

Cell.Available online 25 October 2018.

Cell.2018 Sep 27. pii: S0092-8674(18)31183-8.

Cell.2018 Jun 28;174(1):172-186.e21.

Cell.2018 Feb 22;172(5):1007-1021.e17.

Cell.2017 Nov 30;171(6):1284-1300.e21.

Cell.2017 Aug 17. pii: S0092-8674(17)30869-3.

Cell.2017 Jul 13;170(2):312-323

Nat Med.2018 Jan 29.

Nat Med.2017 Nov;23(11):1342-1351.

Cell.2017 Apr 6;169(2):286-300.

Cell.2015 Aug 27;162(5):987-1002.

Cell.2015 Feb 12;160(4):729-44.

Nature Medicine.2017 Apr;23(4):493-500.

Cancer Cell.2018 May 14;33(5):905-921.e5.

Cancer Cell.2018 Apr 9;33(4):752-769.e8.

Cancer Cell.2018 Mar 12;33(3):401-416.e8.

Cancer Cell.2017 Aug 14;32(2):253-267.e5.

Nat Methods.2018 Jul;15(7):523-526.

Cell Stem Cell.2018 May 3;22(5):769-778.e4.

Cell Stem Cell.2017 Nov 20. pii: S1934-5909(17)30375-2.

HTS Facility Partners

Featured Products of the Panel

Catalog No.	Product Name	Summary	Targets	CAS Number	Smiles
A2150	Andarine	Selective androgen receptor agonist	Endocrinology and Hormones\|Androgen Receptor	401900-40-1	C(=O)NC1=CC=C(C=C1)OCC(C)(C(=O)NC2=CC(=C(C=C2)[N+](=O)[O-])C(F)(F)F)O
B1534	AZD1981	CRTh2 antagonist,potent and selective	Endocrinology and Hormones\|CRTH2	802904-66-1	CC1=C(C2=C(N1CC(=O)O)C=CC=C2NC(=O)C)SC3=CC=C(C=C3)Cl
A1428	Fulvestrant	Estrogen receptor antagonist,high affinity	Endocrinology and Hormones\|Estrogen/progestogen Receptor	129453-61-8	CC12CCC3C(C1CCC2O)C(CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F
B1518	Erteberel (LY500307)	Erβ agonist, potent and selective	Endocrinology and Hormones\|Estrogen/progestogen Receptor	533884-09-2	C1CC2C(C1)C3=C(C=CC(=C3)O)OC2C4=CC=C(C=C4)O
B3238	XCT790	ERRα agonist	Endocrinology and Hormones\|Estrogen/progestogen Receptor	725247-18-7	COC1=C(C=CC(=C1)C=C(C#N)C(=O)NC2=NN=C(S2)C(F)(F)F)OCC3=C(C=C(C=C3)C(F)(F)F)C(F)(F)F
A2986	ADL5859 HCl	δ-opioid receptor agonist,selective	Endocrinology and Hormones\|Opioid Receptor	850173-95-4	CCN(CC)C(=O)C1=CC=C(C=C1)C2=CC3(CCNCC3)OC4=C2C(=CC=C4)O.Cl
A8456	JTC-801	KOR-3 (NOP) receptor antagonist, high affinity and selective	Endocrinology and Hormones\|Opioid Receptor	244218-51-7	CCC1=CC=C(C=C1)OCC2=CC=CC=C2C(=O)NC3=CC4=C(C=C3)N=C(C=C4N)C.Cl	A8019	Perindopril Erbumine	Potent angiotensin-converting enzyme (ACE) inhibitor	Endocrinology and Hormones\|RAAS	107133-36-8	CCCC(C(=O)OCC)NC(C)C(=O)N1C2CCCCC2CC1C(=O)O.CC(C)(C)N
Download the Endocrinology and Hormones-related Compounds Panel - XLSXDownload the Endocrinology and Hormones-related Compounds Panel - SDF

Quality Control

Related Biological Data

KLK3 (top) and NKX3-1(bottom) expression which were the AR target genes in various resistant clones were analyzed by QPCR.All lines were pretreated with vehicle (−) or doxycycline (+) for 3 days before treatment with DMSO (left) or 10 μmol/L MDV3100 (right) for 24 hours in 10% FCS. TBP was used to normalize expression. Data represent mean ± SEM; n = 3. *, P < 0.05;="" **,="" p="">< 0.01="" (student="" t="" test).="" the="" f876l="" mutation="" is="" sufﬁcient="" to="" induce="" genetic="" and="" phenotypic="" resistance="" to="" mdv3100.="">

Review (Georgia Regents University)

Comparison of different anti-androgen/AR compounds on TGF-β1/Smad3/MMP9 signaling in PCa cells. CWR22Rv1 cells treated with 10 μM CASO, 10 μM MDV, 10 μM ASC, 5 μM CTS, or vehicle for 3 days were harvested. The expressions of TGF-β1, p-Smad3, Smad3, MMP9, and GAPDH were analyzed by Western blot analysis. All of the experiments have been repeated twice independently. *, p< 0.05;="" **,="" p="">< 0.01;="" ***,="" p="">< 0.001.="" error="" bars,="" s.d.="" casodex="" and="" mdv3100="" enhanced="" tgf-beta,="" mmp9="" expression="" in="" cwr22rv1="" cells.="" whereas="" asc-j9="" and="" cts="" treatment="" did="" not.="">

Review (University of Glasgow )

Chronic exposure to ENZA resulted in autophagy. To mimic resistant to ENZA, C4-2B cells were subjected to 20 μM ENZA over a period of 3 months and selected for a sub-population of resistance cells (C4-2B+R). Upper panel showed acridine orange staining of autophagosome acidic vesicles as a marker for autophagy. Lower panel showed LC3-I/II protein expression in parental cells (control) and under chronic ENZA exposure-treated vehicle control, chloroquine (CQ) or CMI. β -Actin was used as the loading control.

Signaling Pathway

Androgen Receptor Compare Products

Product Name	Androgen Receptor	Other Targets
Cyproterone Acetate	****	Androgen Receptor
TOK-001	**	CYP17
AZD3514	*
ARN-509	***	GABAA receptor
PF 998425	***
Bicalutamide	**
MDV3100 (Enzalutamide)	***
17 alpha-propionate	*
ASC-J9	*
RU 58841	*
Flutamide	***
Spironolactone	***

Product Name	Androgen Receptor	Other Targets
Cyproterone Acetate	*
TCPOBOP	***
CITCO	***
Cl-4AS-1	***	5α-reductase type I5α-reductase type II
TFM-4AS-1	***	5α-reductase type I5α-reductase type II
Andarine	****
MK-2866 (GTx-024)	*
BMS-564929	****
MK-0773	****

Estrogen/progestogen Receptor Compare Products

Opioid Receptor Compare Products

Opioid Receptor Inhibitors
Opioid Receptor Activators
Hover mouse over "" to show IC50

Product Name	Opioid-receptor	μ-opioid receptor	μ1-opioid receptor	κ-opioid receptor	δ-opioid receptor	δ1-opioid receptor	δ2-opioid receptor
Alvimopan		*
CTOP		****
Naltrexone HCl	*
Naloxone HCl	*
Alvimopan dihydrate		***
Alvimopan monohydrate		***
JDTic				*
JDTic 2HCl				*
LY2795050				****
Naltrexone	*
JTC-801
Diprenorphine		*****		*****	****
Nalmefene - d3	*
Nalmefene hydrochloride	*
Methylnaltrexone Bromide		*
β-Funaltrexamine hydrochloride		*
BNTX maleate						*
DIPPA hydrochloride				*
N-Benzylnaltrindole hydrochloride							*
Naltrindole hydrochloride					*
SDM25N hydrochloride					***
GNTI dihydrochloride				****
ML 190				*
Naltriben mesylate		**		*	*****
ICI 174,864					*
Naloxonazine dihydrochloride			*
Clocinnamox mesylate		****		***	***
ICI 154,129					*
Cyprodime hydrochloride		***			*
CTAP		***
nor-Binaltorphimine dihydrochloride				*

Notes:1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)2.For more details about the compound, click on the product name of your interest.3."" represents potency. The higher the number of "" is, the more potent the inhibitor or activator is.

Advantages

Available in stock with overnight delivery and free shipping over $500
Cost-effective and competitive price to save your findings
Potent, selective and cell-permeable in inhibiting or activating target molecules
Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.)
Detailed files describing potency, selectivity and applications etc.
Supported by published data from top peer-reviewed journals
Guaranteed high quality with NMR and HPLC validation

Storage and Shipping Information

Solubility	Soluble in DMSO	Storage	Desiccate at -20°C
Packaging	96 well plate	Form	Powder
General tips	For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.
Shipping Condition	Evaluation sample solution : ship with blue iceAll other available size:ship with RT , or blue ice upon request

Background

A wide range of well-characterized bioactive molecules that covers various targets related to endocrinology and hormones, including androgen receptor, estrogen/progestogen receptor and RAAS etc. Facilitate your research towards the insights of diabetes, thyroid disorders and cancer etc. Applicable in cellular assays, animal models and drug screenings etc.

References

1. Kaarbø M, Klokk TI, Saatcioglu F. Androgen signaling and its interactions withother signaling pathways in prostate cancer. Bioessays. 2007 Dec;29(12):1227-38.Abstract The androgen receptor (AR) is required for prostate cancer growth in all stages. This review focuses on AR function and AR-target genes and summarizes the major signaling pathways implicated in prostate cancer progression, their crosstalk with each other and with AR signaling. This complex network of interactions is providing a deeper insight into prostate carcinogenesis and may form the basis for novel diagnostic and therapeutic strategies.

品牌介绍

ApexBio是用于生物学研究的肽和实验室试剂的主要提供商。我们在细胞凋亡，表观遗传学，癌症生物学等研究领域拥有广泛的产品线。Apexbio还提供定制服务，包括肽合成，抗体生产和测定开发。

公司介绍

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产品分类

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Growth Factors Nature Products Tag Peptides Biotinylation reagents and kits Others DNA/RNA Kit Screening Panel Signaling Pathways

销售排行

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ApexBio/GSK837149A/5mg/C5075

$526.00

ApexBio/BLZ945/10mM (in 1mL DMSO)/B4899

$680.00

ApexBio/2-Imino-4-methylpiperidine (acetate)/10mg/C5658

$198.00

ApexBio/ACET/10mg/B7161

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ApexBio/GW788388/10mM (in 1mL DMSO)/A8301

$385.00

问答列表

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Product Name	Estrogen receptor	Estrogen receptor-α	Estrogen receptor-β	Estrogen-related receptors
(E)-2-Decenoic acid			*
Bazedoxifene HCl		***	***
Equol		*	*
Estriol	*
Hexestrol		*****	*****
Clomiphene citrate	*
Toremifene Citrate	*
Bazedoxifene		***	***
Bazedoxifene acetate	*
Toremifene	*
Fulvestrant	*****
Raloxifene HCl	****
Endoxifen
Cyclofenil	*
	*
Ospemifene	*
Y 134		*****	***
(R,R)-THC			****
RU 58668	*****
MPP dihydrochloride		****	*
ZK 164015	*
PHTPP			*
XCT790				**
	*
	*

Product Name	opioid-receptor	μ-opioid receptor	μ1-opioid receptor	κ-opioid receptor	δ-opioid receptor	δ1-opioid receptor	κ/δ-opioid heterodimer receptor
Trimebutine		*
Loperamide HCl	*
(±)-U-50488 hydrochloride				*
(-)-U-50488 hydrochloride				*
(+)-U-50488 hydrochloride				*
U-54494A hydrochloride				*
SNC 162					****
AR-M 1000390 hydrochloride					*
Meptazinol HCl			*
Cebranopadol		*
ADL5859 HCl		**		**	****
Morphine hydrochloride	*
Naloxone benzoylhydrazone		***		****	***
[Leu5]-Enkephalin	*
BAM 22P	***
ICI 204,448 hydrochloride				*
ICI 199,441 hydrochloride				*
SNC 80					*
FIT					***
GR 89696 fumarate				*****
Oxycodone hydrochloride		**
Fentanyl citrate		***		*	*
6"-GNTI dihydrochloride							**
N-MPPP Hydrochloride				*
BRL 52537 hydrochloride		*		*
DSLET					*
Endomorphin-2		****
SB 205607 dihydrobromide						***
Dynorphin A				*
Dynorphin B				*
DAMGO		*
[D-Ala2]-Deltorphin II					*
DPDPE					***
Deltorphin I					****
DADLE		*			*
Salvinorin A		*		***
PL 017		***
BW 373U86		**		**	***
Buprenorphine hydrochloride		*		*	*
Oxymorphone	*

Product Name	Estrogen receptor	Estrogen receptor-α	Estrogen receptor-β	Estrogen-related receptors
Erteberel (LY500307)			*****
FERb 033			****
Zearalenone		**	**
ERB 041		*	****
WAY 200070		**	****
GSK 4716				*
(R,R)-THC		****
Estropipate	*
(R)-DPN		**	****
DPN		***	*****
PPT	*****
	*
Equol	*