请使用支持JavaScript的浏览器!
主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
ApexBio/DiscoveryProbe™ DNA Damage/DNA Repair-related Compounds Panel/5mg/well/L1007
产品编号:L1007
市  场 价:¥102200.00
场      地:美国(厂家直采)
产品分类: 蛋白类>聚合物>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$5110.00
品      牌: ApexBio
公      司:ApexBio
公司分类:
ApexBio/DiscoveryProbe™ DNA Damage/DNA Repair-related Compounds Panel/5mg/well/L1007
商品介绍
Related Products
  • VE-822
  • KU 55933
  • Rocilinostat (ACY-1215)
  • SCR7
  • (S)-Crizotinib
  • JNJ-26481585
Molarity CalculatorDilution Calculator
DiscoveryProbe™ DNA Damage/DNA Repair-related Compounds Panel

Catalog No.L1007
SizePriceStockQty
5mg/well
$5,110.00
In stock

Tel: +1-832-696-8203

Email: sales@apexbt.com

Worldwide Distributors

Sample solution is provided at 25 µL, 10mM.

Click and Customize the Panelwith your own choices of compounds/size/quantities/chemical forms etc.

Publications citing ApexBio Products

Nature.2017 Jan 19;541(7637):417-420.
Nature.2018 Nov;563(7731):407-411.
Nature.2018 Jun 13.
Nature.2018 Jun 27.
Nature.2018 Mar 29;555(7698):673-677.
Nature.2017 Sep 7;549(7670):96-100.
Nature.2016 Apr 21;532(7599):398-401.
Science.2016 Aug 5;353(6299)594-8
Nat Nanotechnol.2017 Dec;12(12):1190-1198.
Nature Biotechnology.2017 Jun;35(6):569-576
Nat Med.2018 Sep 17.
Cell.2018 Dec 21. pii: S0092-8674(18)31561-7.
Cell.Available online 25 October 2018.
Cell.2018 Sep 27. pii: S0092-8674(18)31183-8.
Cell.2018 Jun 28;174(1):172-186.e21.
Cell.2018 Feb 22;172(5):1007-1021.e17.
Cell.2017 Nov 30;171(6):1284-1300.e21.
Cell.2017 Aug 17. pii: S0092-8674(17)30869-3.
Cell.2017 Jul 13;170(2):312-323
Nat Med.2018 Jan 29.
Nat Med.2017 Nov;23(11):1342-1351.
Cell.2017 Apr 6;169(2):286-300.
Cell.2015 Aug 27;162(5):987-1002.
Cell.2015 Feb 12;160(4):729-44.
Nature Medicine.2017 Apr;23(4):493-500.
Cancer Cell.2018 May 14;33(5):905-921.e5.
Cancer Cell.2018 Apr 9;33(4):752-769.e8.
Cancer Cell.2018 Mar 12;33(3):401-416.e8.
Cancer Cell.2017 Aug 14;32(2):253-267.e5.
Nat Methods.2018 Jul;15(7):523-526.
Cell Stem Cell.2018 May 3;22(5):769-778.e4.
Cell Stem Cell.2017 Nov 20. pii: S1934-5909(17)30375-2.

HTS Facility Partners

HTS Facility Partners

Featured Products of the Panel

Catalog No.Product NameSummaryTargetsCAS NumberSmiles
A4605KU 55933ATM inhibitor,potent and selectiveDNA Damage/DNA Repair|ATM/ATR587871-26-9C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4
B1383VE-822ATR inhibitorDNA Damage/DNA Repair|ATM/ATR1232416-25-9CC(C)S(=O)(=O)C1=CC=C(C=C1)C2=CN=C(C(=N2)C3=CC(=NO3)C4=CC=C(C=C4)CNC)N
A8705SCR7DNA ligase IV inhibitorDNA Damage/DNA Repair|DNA Ligases1533426-72-0S=C(NC(/N=C/C1=CC=CC=C1)=C2/N=C/C3=CC=CC=C3)NC2=O
A4083Rocilinostat (ACY-1215)Selective HDAC6 inhibitorDNA Damage/DNA Repair|HDAC1316214-52-4C1=CC=C(C=C1)N(C2=CC=CC=C2)C3=NC=C(C=N3)C(=O)NCCCCCCC(=O)NO
A4090JNJ-26481585Potent HDAC inhibitorDNA Damage/DNA Repair|HDAC875320-29-9CN1C=C(C2=CC=CC=C21)CNCC3CCN(CC3)C4=NC=C(C=N4)C(=O)NO
A8802(S)-CrizotinibPotent MTH1 inhibitorDNA Damage/DNA Repair|MTH1 CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
A1945BIBR 1532Telomerase inhibitor,novel and selectiveDNA Damage/DNA Repair|Telomerase321674-73-1CC(=CC(=O)NC1=CC=CC=C1C(=O)O)C2=CC3=CC=CC=C3C=C2
A3966DoxorubicinTopo II inhibitor,immunosuppresive antineoplastic antibioticDNA Damage/DNA Repair|Topoisomerase23214-92-8CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O
Download the DNA Damage/DNA Repair-related Compounds Panel - XLSXDownload the DNA Damage/DNA Repair-related Compounds Panel - SDF

Quality Control

Related Biological Data

Trichostatin A
RPE cells were treated with TSA at various concentrations (0.2, 0.4, 0.8 and 1.0 μM). The protein expression levels of cyclinD1, CDK4 and CDK6, p-Rb, P21 and P27 were detected by western blot.

Related Biological Data

Trichostatin A
TSA replaces FGF-2 in the reprogramming process

Related Biological Data

Trichostatin A

Related Biological Data

KU 55933

Related Biological Data

KU 55933

Related Biological Data

KU 55933

Signaling Pathway

PARP Research Area
PARP Compare Products
HDAC Compare Products
Topoisomerase Compare Products

Advantages

  • Cost-effective and competitive price to save your findings
  • Potent, selective and cell-permeable in inhibiting or activating target molecules
  • Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.)
  • Detailed files describing potency, selectivity and applications etc.
  • Supported by published data from top peer-reviewed journals
  • Guaranteed high quality with NMR and HPLC validation

Storage and Shipping Information

SolubilitySoluble in DMSOStorageDesiccate at -20°C
Packaging96 well plateFormPowder
General tipsFor obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.
Shipping ConditionEvaluation sample solution : ship with blue iceAll other available size:ship with RT , or blue ice upon request

Background

A wide range of well-characterized bioactive molecules that covers various targets related to DNA damage/DNA repair, including ATM/ATR, HDAC, and topoisomerase etc. Facilitate your research towards the insights of cancer, genome instability and immune diseases etc. Applicable in cellular assays, animal models and drug screenings etc.

References

1. Lord CJ, Ashworth A. The DNA damage response and cancer therapy. Nature. 2012 Jan 18;481(7381):287-94.Abstract Genomic instability is probably the combined effect of DNA damage, tumour-specific DNA repair defects, and a failure to stop or stall the cell cycle before the damaged DNA is passed on to daughter cells. A better understanding of the cellular response to DNA damage will not only inform our knowledge of cancer development but also help to refine the classification as well as the treatment of the disease.
2. Park J, Thomas S, Munster PN. Epigenetic modulation with histone deacetylaseinhibitors in combination with immunotherapy. Epigenomics. 2015;7(4):641-52.Abstract HDAC inhibitors have been approved as single agents for cutaneous and peripheral T-cell lymphoma and have shown promising activity in reversing therapy resistance in other tumor types. This review describes the current understanding on integrating HDAC inhibitors into various immunotherapeutic approaches, such as cancer vaccines, adoptive T-cell transfer and immune checkpoint inhibitors. Furthermore, it summarizes promising treatment strategies in epigenetic immune priming from clinical trials that are currently underway.
品牌介绍


ApexBio是用于生物学研究的肽和实验室试剂的主要提供商。我们在细胞凋亡,表观遗传学,癌症生物学等研究领域拥有广泛的产品线。Apexbio还提供定制服务,包括肽合成,抗体生产和测定开发。


自营商城图标
厂家直采
全球直采 正品优价
正品保障图标
正品保障
厂家直发 有线跟踪
解放采购图标
正规清关
CIF100%正规报关,提供发票
及时交付图标
及时交付
限时必达 不达必赔