ApexBio/DiscoveryProbe™ Cell Cycle/Checkpoint-related Compounds Panel/5mg/well/L1005,ApexBio,,ApexBio,apexbt,+,,Array.Array蚂蚁淘厂家直采.

产品名称：ApexBio/DiscoveryProbe™ Cell Cycle/Checkpoint-related Compounds Panel/5mg/well/L1005

产品编号：L1005

市场价：¥107600.00

场地：美国(厂家直采)

产品分类：蛋白类>聚合物>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$5380.00

品牌： ApexBio

公司：ApexBio

公司分类：

商品介绍

Size	Price	Stock	Qty
5mg/well	$5,380.00	In stock

Publications citing ApexBio Products

Nature.2017 Jan 19;541(7637):417-420.

Nature.2018 Nov;563(7731):407-411.

Nature.2018 Jun 13.

Nature.2018 Jun 27.

Nature.2018 Mar 29;555(7698):673-677.

Nature.2017 Sep 7;549(7670):96-100.

Nature.2016 Apr 21;532(7599):398-401.

Science.2016 Aug 5;353(6299)594-8

Nat Nanotechnol.2017 Dec;12(12):1190-1198.

Nature Biotechnology.2017 Jun;35(6):569-576

Nat Med.2018 Sep 17.

Cell.2018 Dec 21. pii: S0092-8674(18)31561-7.

Cell.Available online 25 October 2018.

Cell.2018 Sep 27. pii: S0092-8674(18)31183-8.

Cell.2018 Jun 28;174(1):172-186.e21.

Cell.2018 Feb 22;172(5):1007-1021.e17.

Cell.2017 Nov 30;171(6):1284-1300.e21.

Cell.2017 Aug 17. pii: S0092-8674(17)30869-3.

Cell.2017 Jul 13;170(2):312-323

Nat Med.2018 Jan 29.

Nat Med.2017 Nov;23(11):1342-1351.

Cell.2017 Apr 6;169(2):286-300.

Cell.2015 Aug 27;162(5):987-1002.

Cell.2015 Feb 12;160(4):729-44.

Nature Medicine.2017 Apr;23(4):493-500.

Cancer Cell.2018 May 14;33(5):905-921.e5.

Cancer Cell.2018 Apr 9;33(4):752-769.e8.

Cancer Cell.2018 Mar 12;33(3):401-416.e8.

Cancer Cell.2017 Aug 14;32(2):253-267.e5.

Nat Methods.2018 Jul;15(7):523-526.

Cell Stem Cell.2018 May 3;22(5):769-778.e4.

Cell Stem Cell.2017 Nov 20. pii: S1934-5909(17)30375-2.

HTS Facility Partners

Featured Products of the Panel

Catalog No.	Product Name	Summary	Targets	CAS Number	Smiles
A2521	VE-821	ATR kinase inhibitor,potent and selective	Cell Cycle/Checkpoint\|ATM/ATR	1232410-49-9	CS(=O)(=O)C1=CC=C(C=C1)C2=CN=C(C(=N2)C(=O)NC3=CC=CC=C3)N
A8807	MK-8745	Aurora A inhibitor,potent and selective	Cell Cycle/Checkpoint\|Aurora Kinase	885325-71-3	ClC1=C(F)C(C(N2CCN(CC3=NC(NC4=NC=CS4)=CC=C3)CC2)=O)=CC=C1
A8394	CHIR-124	Chk1 inhibitor,novel and potent	Cell Cycle/Checkpoint\|Chk	405168-58-3	C1CN2CCC1C(C2)NC3=C4C=C(C=CC4=NC(=O)C3=C5NC6=CC=CC=C6N5)Cl
B1236	BML-277	Chk2 inhibitor,potent and highly selective	Cell Cycle/Checkpoint\|Chk	516480-79-8	C1=CC(=CC=C1C2=NC3=C(N2)C=C(C=C3)C(=O)N)OC4=CC=C(C=C4)Cl
A1794	LY2835219	CDK4/6 inhibitor,potent and selective	Cell Cycle/Checkpoint\|Cyclin-Dependent Kinases	1231930-82-7	CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F.CS(=O)(=O)O
A8412	Dinaciclib (SCH727965)	Potent CDK inhibitor	Cell Cycle/Checkpoint\|Cyclin-Dependent Kinases	779353-01-4	CCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCCC4CCO
A8882	THZ1	Covalent CDK7 inhibitor,potent and selective	Cell Cycle/Checkpoint\|Cyclin-Dependent Kinases		ClC1=CN=C(N=C1C2=CNC3=CC=CC=C23)NC4=CC=CC(NC(C5=CC=C(NC(/C=C/CN(C)C)=O)C=C5)=O)=C4
A4393	Paclitaxel (Taxol)	Antineoplastic agent	Cell Cycle/Checkpoint\|Cytoskeleton	33069-62-4	O=C(N[C@H]([C@H](C(O[C@H]1C[C@]2(O)C(C)(C)C([C@@H](OC(C)=O)C([C@@]3(C)[C@]([C@@](CO4)(OC(C)=O)[C@H]4C[C@@H]3O)([H])[C@@H]2OC(C5=CC=CC=C5)=O)=O)=C1C)=O)O)C6=CC=CC=C6)C7=CC=CC=C7
Download the Cell Cycle/Checkpoint-related Compounds Panel - XLSXDownload the Cell Cycle/Checkpoint-related Compounds Panel - SDF

Quality Control

Related Biological Data

Related Biological Data

Related Biological Data

Signaling Pathway

Aurora Kinase Research Area

Aurora Kinase Compare Products

Product Name	Aurora A	Aurora B	Aurora C	Other Targets
MLN8237 (Alisertib)	****
MK-8745	*****
Reversine	**	*	**
AZD1152	*	*****
Barasertib (AZD1152-HQPA)		*****
ZM 447439	*	***	**
VX-680 (MK-0457,Tozasertib)	*****	****	***	FLT3Bcr-Abl
Aurora A Inhibitor I	****
GSK1070916		****	****
PF-03814735	*****	****		Flt 1FAk
SCH-1473759	****	***
XL228	****			IGF1RFGFR1-3ABLSRC
TC-A 2317 hydrochloride	****	**
CYC116	****	****		VEGFR2CDKs
TAK-901	***	***
SNS-314 Mesylate	****	***	****
AMG-900	****	****	*****
Hesperadin		**		TbAUK1
CCT137690	***	***	***
ENMD-2076	***	***		Flt3
ENMD-2076 L-(+)-Tartaric acid	***	**		Flt3
CCT129202	***	**	**
MLN8054	****	**
JNJ-7706621	***	***		CDK1CDK2CDK3
Danusertib (PHA-739358)	***	***	***	Bcr-Ablc-RETFGFRTrkA
AT9283	****	****		JAK2JAK3c-Abl
MK-5108 (VX-689)	*****	***	***
PHA-680632	***	**	**

Product Name	Aurora A	Aurora B	Aurora C	Other Targets
Anacardic acid	*			p300

Cyclin-Dependent Kinases Research Area

Cyclin-Dependent Kinases Compare Products

CDK Inhibitors
Hover mouse over "" to show IC50

Product Name	Pan-CDK	CDK1	CDK2	CDK3	CDK4	CDK5	CDK6	CDK7	CDK8	CDK9	CDK1/cyclin A	CDK1/cyclin B	CDK1/cyclin B1	CDK2/cyclin A	CDK2/cyclin E	Cdc2/cyclin A	Cdc/cyclin B	Cdc2/cyclin B	CDK3/cyclin E	CDK4/cyclin D	CDK4/cyclin D1	CDK4/cyclin D3	CDK5/p35	CDK5/p25	CDK6/cyclin D2	CDK6/cyclin D3	CDK7/cyclin H	CDK9/cyclin T	CDK9/cyclin T1	Other Targets
AZD-5438		***	****							***			***	***	****
THZ1								****
LEE011					*		*
Dinaciclib (SCH727965)		****	*****			*****				****
[Ala92]-p16 (84-103)																					*
Senexin A									**
Arcyriaflavin A																					***									CaM kinase IIPKAPKC
Kenpaullone												**		**	*								**							GSK-3βc-srccasein kinase 2ERK1ERK2
CDK4 inhibitor												*		*							****
Flavopiridol hydrochloride		***	***		***		***	**																						EGFRPKA
Flavopiridol		***	***		***		***	**																						EGFRPKA
Deferasirox
Purvalanol B	*	*	*		*									****	****			****			*		****
BMS265246												****			****					**
NSC 693868												**												**						GSK-3
Aminopurvalanol A												***		***	***								***							ERK1ERK2Arrests cell cycle at G2/M boundary
Ro 3306											**		***
RGB-286638 free base													****		****				****		****		****			***	***		*****	GSK-3βTAK1AMPKJak2MEK1
RGB-286638													****		****				****		****		****			***	***		*****	GSK-3βTAK1AMPKJak2MEK1
LY2857785										*
(R)-DRF053 dihydrochloride												**												****						CK1GSK-3 αβ
Ryuvidine																					*									SETD8 protein lysine methyltransferase (PKMT)
NSC 625987														*	*	*					**
PHA-848125												**		***	**						**		**				**			TrkA
Palbociclib (PD0332991) Isethionate					***		***														***	****			***
CVT-313												*		**	**						*									MAPKPKAPKC
CGP60474	*																													PKC
CDK9 inhibitor 2										*
CDK9 inhibitor										***
CDK inhibitor II	*
BS-181		*	*		*	*	*	***		*
BS-181 HCl		*	*		*	*	*	***		*
AT7519 trifluoroacetate												**		***	**						***		***			**
AT7519 Hydrochloride		*	*		*	*	*			*		**		***					**		***		***			**	*	****		GSK-3β
AT7519		*	*		*	*	*			*		**		***					**		***		***			**	*	****		GSK-3β
LY2835219 free base					****		****
LY2835219					****		****
NVP-LCQ195		*	*	*		*				*		****		****	****				***				*****	*****
PD 0332991 (Palbociclib) HCl					***		***
PHA-793887												***		****	****									****			****
Roscovitine (Seliciclib,CYC202)															***		**						**				**
SNS-032 (BMS-387032)			***					***		****
SCH900776 S-isomer			**																											checkpoint kinase Chk1Chk2
SB1317		*	***					*		*																				JAK2FLT3
Nu 6027		*	*
LDC000067		**	***		**		**	**		***
LEE011 succinate hydrate																					*					*
LEE011 succinate																					*					*
LEE011 hydrochloride																					*					*
WHI-P180 hydrochloride			*																											EGFR
WHI-P180			*																											EGFR
AMG 925					****																									FLT3
R547												****			****						*****									PKAPKB
SU 9516		***	***		**																									PKCp38PDGFREGFR
CDK7-IN-1								*
THZ1 Hydrochloride								****

Notes:1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)2.For more details about the compound, click on the product name of your interest.3."" represents potency. The higher the number of "" is, the more potent the inhibitor or activator is.

Advantages

Available in stock with overnight delivery and free shipping over $500
Cost-effective and competitive price to save your findings
Potent, selective and cell-permeable in inhibiting or activating target molecules
Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.)
Detailed files describing potency, selectivity and applications etc.
Supported by published data from top peer-reviewed journals
Guaranteed high quality with NMR and HPLC validation

Storage and Shipping Information

Solubility	Soluble in DMSO	Storage	Desiccate at -20°C
Packaging	96 well plate	Form	Powder
General tips	For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.
Shipping Condition	Evaluation sample solution : ship with blue iceAll other available size:ship with RT , or blue ice upon request

Background

A wide range of well-characterized bioactive molecules that covers various targets related to cell cycle/checkpoint, including Chk, CDK and Plk etc. Facilitate your research towards the insights of DNA replication, tumorgenesis and aging etc. Applicable in cellular assays, animal models and drug screenings etc.

品牌介绍

ApexBio是用于生物学研究的肽和实验室试剂的主要提供商。我们在细胞凋亡，表观遗传学，癌症生物学等研究领域拥有广泛的产品线。Apexbio还提供定制服务，包括肽合成，抗体生产和测定开发。

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Growth Factors Nature Products Tag Peptides Biotinylation reagents and kits Others DNA/RNA Kit Screening Panel Signaling Pathways

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