ApexBio/DiscoveryProbe™ Apoptosis-related Compounds Panel/5mg/well/L1002,ApexBio,,ApexBio,apexbt,+,,Array.Array蚂蚁淘厂家直采.

产品名称：ApexBio/DiscoveryProbe™ Apoptosis-related Compounds Panel/5mg/well/L1002

产品编号：L1002

市场价：¥43980.00

场地：美国(厂家直采)

产品分类：蛋白类>聚合物>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$2199.00

品牌： ApexBio

公司：ApexBio

公司分类：

商品介绍

Size	Price	Stock	Qty
5mg/well	$2,199.00	In stock

Publications citing ApexBio Products

Nature.2017 Jan 19;541(7637):417-420.

Nature.2018 Nov;563(7731):407-411.

Nature.2018 Jun 13.

Nature.2018 Jun 27.

Nature.2018 Mar 29;555(7698):673-677.

Nature.2017 Sep 7;549(7670):96-100.

Nature.2016 Apr 21;532(7599):398-401.

Science.2016 Aug 5;353(6299)594-8

Nat Nanotechnol.2017 Dec;12(12):1190-1198.

Nature Biotechnology.2017 Jun;35(6):569-576

Nat Med.2018 Sep 17.

Cell.2018 Dec 21. pii: S0092-8674(18)31561-7.

Cell.Available online 25 October 2018.

Cell.2018 Sep 27. pii: S0092-8674(18)31183-8.

Cell.2018 Jun 28;174(1):172-186.e21.

Cell.2018 Feb 22;172(5):1007-1021.e17.

Cell.2017 Nov 30;171(6):1284-1300.e21.

Cell.2017 Aug 17. pii: S0092-8674(17)30869-3.

Cell.2017 Jul 13;170(2):312-323

Nat Med.2018 Jan 29.

Nat Med.2017 Nov;23(11):1342-1351.

Cell.2017 Apr 6;169(2):286-300.

Cell.2015 Aug 27;162(5):987-1002.

Cell.2015 Feb 12;160(4):729-44.

Nature Medicine.2017 Apr;23(4):493-500.

Cancer Cell.2018 May 14;33(5):905-921.e5.

Cancer Cell.2018 Apr 9;33(4):752-769.e8.

Cancer Cell.2018 Mar 12;33(3):401-416.e8.

Cancer Cell.2017 Aug 14;32(2):253-267.e5.

Nat Methods.2018 Jul;15(7):523-526.

Cell Stem Cell.2018 May 3;22(5):769-778.e4.

Cell Stem Cell.2017 Nov 20. pii: S1934-5909(17)30375-2.

HTS Facility Partners

Featured Products of the Panel

Catalog No.	Product Name	Summary	Targets	CAS Number	Smiles
A3007	ABT-263 (Navitoclax)	Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w	Apoptosis\|Bcl-2 Family	923564-51-6	CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C
A4465	MIM1	Mcl-1 Inhibitor	Apoptosis\|Bcl-2 Family		OC1=CC=C(/C=N/N2C(C)=CS/C2=NC3CCCCC3)C(O)=C1O
A8194	ABT-199	Bcl-2 inhibitor,potent and selective	Apoptosis\|Bcl-2 Family	1257044-40-8	CC1(CCC(=C(C1)C2=CC=C(C=C2)Cl)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)NS(=O)(=O)C5=CC(=C(C=C5)NCC6CCOCC6)[N+](=O)[O-])OC7=CN=C8C(=C7)C=CN8)C
B4881	UMI-77	Mcl-1 inhibitor	Apoptosis\|Bcl-2 Family	518303-20-3	C1=CC=C2C(=C1)C(=CC(=C2O)SCC(=O)O)NS(=O)(=O)C3=CC=C(C=C3)Br
A1901	Q-VD-OPh hydrate	Cell-permeable, irreversible pan-caspase inhibitor	Apoptosis\|Caspase	1135695-98-5	CC(C)C(C(=O)NC(CC(=O)O)C(=O)COC1=C(C=CC=C1F)F)NC(=O)C2=NC3=CC=CC=C3C=C2
A1902	Z-VAD-FMK	Cell-permeable, irreversible pan-caspase inhibitor	Apoptosis\|Caspase	187389-52-2	CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1
Download the Apoptosis related Compounds Panel - XLSXDownload the Apoptosis related Compounds Panel - SDF

Quality Control

Related Biological Data

ABT-737, or ABT-263 at the indicated doses for 24 hours. Survival data are shown for transitional B cells (n = 3 mice for each genotype) and are the results of 3 independent experiments, each performed in triplicate. Experiments depicted in panels C and D were performed concurrently. Values represent mean ± SEM.

Related Biological Data

As an inhibitor of Bcl-2, ABT263 is effective to reduce cell viability in HG3-CLL cells. Incubating the cells with ABT263 in 96 well plates (3×104 cells per well) for 24h shows a dose-dependent inhibition of cell viability with EC50 value of 2μM.[Source: Istituto di Scienze dell’Alimentazione]

Related Biological Data

zVAD was able to completely suppress the proteolytic processing of Panx1 at each incubation time point in the anti-Fas treated Jurkat cells [1].

1. Boyd-Tressler A, Penuela S, Laird D W, et al. Chemotherapeutic Drugs Induce ATP Release via Caspase-gated Pannexin-1 Channels and a Caspase/Pannexin-1-Independent Mechanism. Journal of Biological Chemistry, 2014: jbc. M114. 590240.

Related Biological Data

Signaling Pathway

Caspase Research Area

P53 Research Area

Bcl-2 Family Research Area

Advantages

Available in stock with overnight delivery and free shipping over $500
Cost-effective and competitive price to save your findings
Potent, selective and cell-permeable in inhibiting or activating target molecules
Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.)
Detailed files describing potency, selectivity and applications etc.
Supported by published data from top peer-reviewed journals
Guaranteed high quality with NMR and HPLC validation

Storage and Shipping Information

Solubility	Soluble in DMSO	Storage	Desiccate at -20°C
Packaging	96 well plate	Form	Powder
General tips	For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.
Shipping Condition	Evaluation sample solution : ship with blue iceAll other available size:ship with RT , or blue ice upon request

Background

A wide range of well-characterized bioactive molecules that covers various targets related to apoptosis, including caspase, MDM2 and Bcl-2 etc. Facilitate your research towards the insights of cancer, degenerative diseases and autoimmunity etc. Applicable in cellular assays, animal models and drug screenings etc.

References

1. Fuchs Y, Steller H. Programmed cell death in animal development and disease.Cell. 2011 Nov 11;147(4):742-58. doi: 10.1016/j.cell.2011.10.033. Review. Erratumin: Cell. 2011 Dec 23;147(7):1640.Abstract Programmed Cell Death (PCD) plays a fundamental role in animal development and tissue homeostasis. We focus on the function and regulation of apoptotic proteins, including caspases, the key executioners of apoptosis, highlighting the functions of these proteins in cell differentiation and tissue remodeling. Finally, we explore the connections between apoptosis, stem cells and cancer, focusing on how apoptotic cells release a variety of signals to communicate with their cellular environment, including factors that promote cell division, tissue regeneration, and wound healing.

2. Abrams MJ, Basinger T, Yuan W, Guo CL, Goentoro L. Self-repairing symmetry in jellyfish through mechanically driven reorganization. Proc Natl Acad Sci U S A.2015 Jun 30;112(26):E3365-73.Abstract In this study, we report a previously unidentified strategy of self-repair, where moon jellyfish respond to injuries by reorganizing existing parts, and rebuilding essential body symmetry, without regenerating what is lost. we find that forces generated by the muscular network are essential for symmetrization. Furthermore, decreasing pulse frequency using muscle relaxants slowed symmetrization, whereas increasing pulse frequency by lowering the magnesium concentration in seawater accelerated symmetrization. Self-repair in Aurelia proceeds through the reorganization of existing parts, and is driven by forces generated by its own propulsion machinery.

品牌介绍

ApexBio是用于生物学研究的肽和实验室试剂的主要提供商。我们在细胞凋亡，表观遗传学，癌症生物学等研究领域拥有广泛的产品线。Apexbio还提供定制服务，包括肽合成，抗体生产和测定开发。

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